POLYPEPTIDES DERIVED FROM TGF AND USES THEREOF

专利名称：POLYPEPTIDES DERIVED FROM TGF AND

USES THEREOF

发明人：CORRIA OSORIO, Ángel de Jesús,LEÓN

MONZÓN, Kalet,CARMENATE PORTILLA,Tania,PUPO MERIÑO, Amaury,PÉREZRODRÍGUEZ, Saumel

申请号：EP13805228.7申请日：20131030公开号：EP2918284A1公开日：20150916

摘要：The present invention relates to the field of Biotechnology and more

particularly to the mutated polypeptides of TGFβ molecule whose primary sequence hasa high homology with the sequence of human TGFβ. These muteins lose their ability tointeract with ALK5 but maintain their ability to interact with other receptors that are partof the receptor complex (TβRII and TβRIII). They have the property of antagonizing thesignaling of all natural variants of TGFβ ligands, dependent of ALK5 recruitment in thereceptor complex, and have significant immunomodulatory effects. The present inventionrelates to pharmaceutical compositions comprising as active principle the polypeptidesor fusion proteins disclosed and their use thereof given their modulating effect on theimmune system in diseases such as cancer, diseases accompanied by fibrosis and chronicinfectious diseases.

申请人：Centro de Inmunologia Molecular

地址：Calle 216 esq. A 15 Atabey Playa La Habana 11600 CU

国籍：CU

代理机构：Jansen, Cornelis Marinus

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