Telomerase Inhibitors

专利名称：Telomerase Inhibitors

发明人：Federico C. A. Gaeta,Adam Antoni

Galan,Elaine C. Stracker

申请号：US08/424813申请日：19950418公开号：US05703116A公开日：19971230

摘要：Methods and compositions for treating cancer and other diseases in whichinhibition of telomerase activity can ameliorate disease symptoms or prevent or treat thedisease relate to compounds that are derivatives of benzo[b]thiophenes. Suchcompounds are characterized by the following structure: ##STR1## In this compound,R.sub.1 is selected from the group consisting of --OR.sub.7, --NR.sub.8 R.sub.9, --NHNR.sub.10 R.sub.11, -- NHNHC(X.sub.2)NHR.sub.12, --NHSO.sub.2 NR.sub.8 R.sub.9, --NHNHC(O)R.sub. 12, --NHNHSO.sub.2 R.sub.12 and --NHC(O)NR.sub. 8 R.sub.9. R.sub.7 -R.sub. 12 are selected independently from the group consisting of hydrogen, alkyl, aryl,aralkyl, heteroaryl and heteroaralkyl. X.sub.1 and X.sub.2 are selected independentlyfrom the group consisting of oxygen and sulfur. R.sub.2 is hydrogen or halogen. R. sub.3 -R.sub.6 are selected independently from the group consisting of hydrogen, halogen,hydroxyl, -- NR.sub.8 R.sub.9, nitro, cyano, alkoxyl, lower alkyl, aryl and aryloxyl.

申请人：GERON CORPORATION

代理人：David P. Lentini,Kevin R. Kaster

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