Process for the preparation of substituted guanidi

专利名称：Process for the preparation of substituted

guanidines

发明人：DIEHR, HANS-JOACHIM, DR.申请号：EP86103076.5申请日：19860307公开号：EP0195971A2公开日：19861001

摘要：1. Process for the preparation of substituted guanidines of the formula (I) seediagramm : EP0195971,P9,F4 in which R represents a radical see diagramm :

EP0195971,P9,F5 wherein R**7 represents hydrogen or optionally substituted radicalsfrom the series comprising C1-6 -alkyl, C2-7 -alkenyl, C2 -C6 -alkinyl, C1 -C6 -alkoxy, C3 -C8 -cycloalkyl, phenyl and phenoxy, R**8 represents hydrogen, halogen, C1 -C4 -alkyl orC1 -C4 -alkoxy and R**9 represents hydrogen or radicals from the series comprisingphenoxy, phenylthio, benzoyl, phenylsulphinyl and phenylsulphonyl, which are optionallysubstituted by halogen, cyano, nitro, amino, C1 -C4 -alkyl, C1 -C4 -alkoxy, C1 -C4 -alkylthio, halogeno-C1 -C4 -alkyl, halogeno-C1 -C4 -alkoxy, halogeno-C1 -C4 -alkylthioand/or C1 -C4 -alkylcarbonylamino ; or represents radicals from the series comprising C1-C6 -alkyl, C1 -C6 -alkoxy, C1 -C6 -alkylthio, C1 -C6 -alkylsulphinyl, C1 -C6 -alkylsulphonyl,C2 -C6 -alkenyloxy, C2 -C6 -alkenylthio, C2 -C6 -alkenylsulphinyl, C2 -C6 -alkinylsulphonyl,C2 -C6 -alkinyloxy, C2 -C6 -alkinylthio, C2 -C6 -alkinylsulphinyl and C2 -C6 -alkinylsulphonyl, which are optionally substituted by halogen, cyano, C1 -C4 -alkoxyand/or C1 -C4 -alkylthio, R**1 represents aryl which has 6 to 10 carbon atoms and isoptionally substituted by halogen, such as fluorine, chlorine or bromine, C1 -C2 -alkyl, C1

-C2 -alkoxy, C1 -C2 -alkylthio, halogeno-C1 -C2 -alkyl, halogeno-C1 -C2 -alkoxy, halogeno-C1 -C2 -alkylthio, cyano and/or nitro, or represents alkyl having 1 to 6 carbon atoms, andR**2 represents hydrogen or alkyl, alkoxy and alkylthio, each of which has 1 to 6 carbonatoms and is optionally substituted by halogen, cyano, C1 -C4 -alkoxy, C1 -C4 -alkoxycarbonyl and/or by phenoxy which is optionally substituted by halogen, C1 -C2 -alkyl and C1 -C2 -alkoxy ; or represents alkenyl and alkinyl having 2 to 6 carbon atoms ;cycloalkyl having 2 to 8 carbon atoms ; or optionally halogen-substituted or optionallyC1 -C2 -alkoxy-substituted aryl and aryloxy having 6 to 10 carbon atoms, characterised inthat isourea derivatives of the formula (II) see diagramm : EP0195971,P9,F3 in which R**1and R**2 have the meanings given above and R**3 represents alkyl, are reacted withamines of the formule (III) R-NH2 in which R has the meanings given above, if appropriatein the presence of an acid and, if appropriate, in the presence of a diluent.

申请人：BAYER AG

地址：51368 Leverkusen DE

国籍：DE

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