PURIFICATION OF PEPTIDES AND OLIGONUCLEOTIDES BY S

专利名称：PURIFICATION OF PEPTIDES AND

OLIGONUCLEOTIDES BY SAMPLEDISPLACEMENT CHROMATOGRAPHYPROCESS AND APPARATUS

发明人：AGNER, Erik申请号：EP98917381.0申请日：19980416公开号：EP0975658A2公开日：20000202

摘要：Sample displacement chromatography is performed at low operating pressures(less than 30 bar) and/or at high sample loading (in excess of 500 mg/cm2 column area),with product recovery being effected in a non-gradient manner. The low operatingpressures permit the use of simple and inexpensive apparatus. Non-gradient productrecovery allows the desired product to be allowed in solutions with advantageously highconcentration. Materials which may be purified include pharmaceuticals, pharmaceuticalexcipients, fine chemicals, biochemicals, X-ray contrast agents, chelating agents, peptides,proteins, oligonucleotides and vaccines. Apparatus embodiments include sample

displacement chromatography apparatus comprising one or more ion exchange columnsin direct combination with one or more desalting columns, and multicolumn

chromatography apparatus permitting switching between a series separation mode and aparallel extraction mode.

申请人：Marsden, John Christopher,Agner, Erik

地址：Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL GB,Svaneveien

19B 1187 Oslo NO

国籍：GB,NO

代理机构：Marsden, John Christopher

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