Teriflunomide_163451-81-8_DataSheet_MedChemExpress

PdDShProduct Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Teriflunomide163451-81-8HY-15405270.21C12H9F3N2O2>98%Solubility:DMSOMechanisms: Pathways:Others; Target:Others Biological Activity:()ppgTeriflunomide (A77 1726), the active metabolite of an approved antirheumatic drug Leflunomide, isan emerging oral therapy for multiple sclerosis (MS). IC50 value: Target: Teriflunomide has demonstrated anti-inflammatory, antiproliferative and immunosuppressive effects.Teriflunomide is an immunomodulator with a unique mechanism of action. Although the mechanismof action for Teriflunomide is not fully understood, research supports that Teriflunomide inhibits theproliferation of stimulated T and B lymphocytes in the periphery thought to be responsible for thedamaging inflammatory process in MS, while generally maintaining normal immune function.TiflTeriflunomide selectively and reversibly inhibits DHODH, a key enzyme in de novo pyrimidineidltildiblihibitDHODHkidiidisynthesis required by rapidly dividing lymphocytes. Through this effect, it limits the expansion ofstimulated T- and B-cells in t...References:[1]. He D, Xu Z, Dong S, et al. Teriflunomide for multiple sclerosis. Cochrane Database Syst Rev.2012 Dec 12;12:CD009882. [2]PapadopoulouAKapposLSprengerTTeriflunomidefororaltherapyinmultiplesclerosis[2]. Papadopoulou A, Kappos L, Sprenger T. Teriflunomide for oral therapy in multiple sclerosis.Expert Rev Clin Pharmacol. 2012 Nov;5(6):617-28. [3]. Miller AE, O'Connor P, Wolinsky JS, et al. Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis. Mult Scler.2012 Nov;18(11):1625-32. [4]. Xi H, Cun D, Wang Z, et al. Effect of the stability of hydrogen-bonded ion pairs with organicamines on transdermal penetration of teriflunomide. Int J Pharm. 2012 Oct 15;436(1-2):857-61. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr