专利名称：RNA PROCESSING PROTEIN COMPLEXES
AND USES THEREOF
发明人：TROTTA, Christopher, R.,PAUSHKIN, Sergey申请号：EP04777457.5申请日：20040702公开号：EP1649002A2公开日：20060426
摘要：The invention provides human protein complexes with endonuclease activity. Inparticular, the invention provides human protein complexes with tRNA splicing
endonuclease activity and/or 3' end pre-mRNA endonuclease activity. The invention alsoprovides a splice variant of human Sen2, namely human Sen2deltaEx8, and human proteincomplexes comprising human Sen2deltaEx8. The human Sen2deltaEx8 complexes havepre-tRNA cleavage activity and/or 3' end pre-mRNA endonuclease activity. The inventionalso provides human protein complexes with pre-ribosomal RNA cleavage activity. Theinvention also provides antibodies that immunospecifically bind to a complex describedherein or a component thereof, and methods of diagnosing, preventing, treating,managing or ameliorating a disorder utilizing such antibodies. The present invention alsoprovides methods utilizing the complexes described herein, inter alia, in screening,diagnosis, and therapy. The invention further provides methods of preparing and
purifying the complexes. The present invention further provides methods of identifying acompound that modulates the expression of a component of a complex described herein,the formation of a complex described herein or the activity of a complex describedherein, and methods of preventing, treating, managing or ameliorating a disorder, such as
a proliferative disorder, or a symptom thereof utilizing a compound identified inaccordance with the methods.
申请人：PTC Therapeutics, Inc.
地址：100 Corporate Court, Middlesex Business Center South Plainfield, NJ 07080 US
国籍：US
代理机构：Jones Day
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