2-Amino-5-hydroxy-4-methylpyrimidine derivatives

专利名称：2-Amino-5-hydroxy-4-methylpyrimidine

derivatives

发明人：LaMattina, John Lawrence申请号：EP84306575.6申请日：19840927公开号：EP0138464B1公开日：19891115

摘要：Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted aminoderivatives thereof useful as inhibitors of leukotriene synthesis for the treatment ofpulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In additionthese compounds are cytoprotective and therefore useful in the treatment of pepticulcers. A process for the preparation of such active compounds by ring rearrangement of2-amino-5-acetyloxazole, pharmaceutical compositions containing the novel activecompounds and compositions containing these compounds in combination with otheranti-inflammatory agents or gastric anti-secret- t ory agents.

申请人：PFIZER INC.

代理机构：Wood, David John

更多信息请下载全文后查看