PREPARATION OF PROSTAMIDES

专利名称：PREPARATION OF PROSTAMIDES发明人：GARST, MICHAEL, E.,OUDENES,

JAN,ANTCZAK, CASIMIR,GREGORY,MORTIMER, RICHARD,DONALD,LU, YEE-FUNG,HOCHFELLNER,BRIAN, GEORGE,ARSENAULT, EDWARD,ARMAND,YEH, WEN-LUNG

申请号：US0306071申请日：20030228公开号：WO03074481A8公开日：20041021

摘要：The present invention provides a process for the preparation of a prostamidewhich comprises the steps of (d) reacting first intermediate having the general formula (I)with DIBAL wherein Z is a protecting group and the dotted line represents the presenceor absence of a double bond to yield a second intermediate having the general Formula(II) (b) reacting said second intermediate with Na(TMS)2N and (C6H5)3P<+>

(CH2)6CONR2X wherein R is a C1-5 alkyl or hydrogen and X is an anion to yield a thirdintermediate having the general formula (III) (c) reacting said third intermediate with aprotecting agent to yield a fourth intermediate having the general formula IV (e) reactingsaid fourth intermediate to remove said protecting groups and yield a prostamide havingthe general formula V

申请人：ALLERGAN, INC.,GARST, MICHAEL, E.,OUDENES, JAN,ANTCZAK, CASIMIR,GREGORY,MORTIMER, RICHARD, DONALD,LU, YEE-FUNG,HOCHFELLNER, BRIAN,

GEORGE,ARSENAULT, EDWARD, ARMAND,YEH, WEN-LUNG

更多信息请下载全文后查看