专利名称：METHODS AND COMPOSITIONS FOR
INHIBITING THE GROWTH OFHEMATOPOIETIC MALIGNANT CELLS
发明人：Ginette Serrero申请号：US13220307申请日：20110829
公开号：US20120087918A1公开日：20120412
摘要：Disclosed herein are compositions and methods for reducing the growth ofhematopoietic malignant cells (e.g., B-cell leukemia cells). The methods involve reducingthe growth of hematopoietic malignant cells by contacting hematopoietic malignant cellswith GP88 antagonists. GP88 is an 88 KDa autocrine growth factor that promotes thegrowth of hematopoietic malignant cells. Antagonists to GP88 are provided which inhibitits expression or biological activity. The antagonists include antisense oligonucleotidesand antibodies. Also provided are methods for determining if a patient is responding or isresponsive to anti-cancer therapy (e.g., glucocorticoid therapy). Increased levels of GP88in hematopoietic cells indicates a patient is not responding or responsive to anti-cancertherapy.
申请人：Ginette Serrero
地址：Ellicott City MD US
国籍：US
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