专利名称：Treatment of cancers
发明人：Bruce Charles Baguley,Graham John
Atwell,William Alexander Denny,GraemeJohn Finlay,Gordon William Rewcastle
申请号：US08/387565申请日：19950213公开号：US05696131A公开日：19971209
摘要：A new treatment schedule for administration of N-[2- (dimethylamino)ethyl]acridine-4-carboxamide and other related carboxamide anticancer drugs in whichthe drug is administered in a divided-dose schedule comprising two or more
administrations at frequent intervals, for example every hour. Schedules to produce cyclicpeaks/troughs in plasma levels are mentioned. The compounds can be used forcircumventing multidrug resistance in cancers and may, for example, be used incombination with other cytotoxic drugs, especially non-topo II inhibitors. Treatment ofmelanoma and advanced colon cancer is included.
申请人：XENOVA LIMITED
代理机构：Nixon & Vanderhye P
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