专利名称：ROOM TEMPERATURE-CURABLE POLYMERS发明人：HAUENSTEIN, Dale申请号：EP06848882.4申请日：20061214公开号：EP1968486B1公开日：20141119
摘要：Methods of making room temperature-curable polymers. Reactants includesiloxane-terminated polymers and silanols. The reactants are mixed, and thepolymerization allowed to proceed in air at room temperature. The polymers areexceptionally useful because they allow for the incorporation into the polymersthemselves of one or more therapeutic compounds. Thus, medical devices from whichcontrolled drug release is desirable (for either local or systemic delivery) can be coatedwith therapeutic compound-containing polymers of the invention. In a preferredembodiment, a polymer of poly(MPC w :LAM x :HPMA y :TSMA z ) where w, x, y, and zrepresent the molar ratios of monomers used in the feed for preparing the polymer;MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents theunit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, andTSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted withpolydimethylsiloxane. In another preferred embodiment, a therapeutic compound isincorporated into the polymer, such as dexamethasone.
申请人：ABBOTT LAB
地址：US
国籍：US
代理机构：ZBM Patents - Zea, Barlocci & Markvardsen
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