Avacopan-LCMS-25521-MedChemExpress

MS Report from Instrument: LCMS-02 File ..70717 2017-07-17 08-21-57\\FSD4462-004-1_0.D Tgt Mass (CHM): Injection Date : 17 Jul 17 10:53 am +0800 Seq. Line : 32 Sample Name : FSD4462-004-1_0 Location : P1-E-02 Acq. Operator : ZLJ_587 Inj : 1 Spec. Reported : MS Integration Inj Volume : 1 ul Acq. Method : D:\\chem32\\1\\DATA\\20170717\\20170717 2017-07-17 08-21-57\\1-POS-3MIN.M Analysis Method : D:\\chem32\\1\\DATA\\20170717\\20170717 2017-07-17 08-21-57\\1-POS-3MIN.M Catalog No : HY-17627 Batch#25521 A-RP-186 Method Info : Mobile Phase: A: water(0.01%TFA) B:ACN(0.01%TFA) Gradient: 5% to 95%B within 1.3 min Flow Rate :1.8ml/min Column :SunFire C18, 4.6*50mm,3.5um A-RP-186 Oven Temperature : 45C DAD1 B, Sig=214,4 Ref=off mAU0-10-200.5 DAD1 C, Sig=254,4 Ref=off mAU52.50-2.50.511.5 MSD1 TIC, MS File ES-API, Pos, Scan, Frag: 70 **** NO MS PEAKS INTEGRATED ****6000400020000.51 Ion 1, MSD1 1,Target Mass 0 +H Positive, EIC=0.7:1.7 0.050-0.05-0.10.5 Integration Results for DAD1 B, Sig=214,4 Ref=off11.522.5min1.522.5min22.5min11.522.5min RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------| Integration Results for DAD1 C, Sig=254,4 Ref=off RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------| Integration Results for MSD1 TIC, MS File RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------|LCMS-02 7/17/2017 10:56:41 ZLJ_587

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MS Report from Instrument: LCMS-02 File ..0170717 2017-07-17 08-21-57\\FSD4462-004-1.D Tgt Mass (CHM): Injection Date : 17 Jul 17 10:58 am +0800 Seq. Line : 33 Sample Name : FSD4462-004-1 Location : P1-E-03 Acq. Operator : ZLJ_587 Inj : 1 Spec. Reported : MS Integration Inj Volume : 1 ul Acq. Method : D:\\chem32\\1\\DATA\\20170717\\20170717 2017-07-17 08-21-57\\1-POS-3MIN.M Analysis Method : D:\\CHEM32\\1\\DATA\\20170717\\20170717 2017-07-17 08-21-57\\1-POS-3MIN.M Catalog No : HY-17627 Batch#25521 A-RP-186 Method Info : Mobile Phase: A: water(0.01%TFA) B:ACN(0.01%TFA) Gradient: 5% to 95%B within 1.3 min Flow Rate :1.8ml/min Column :SunFire C18, 4.6*50mm,3.5um A-RP-186 Oven Temperature : 45C DAD1 B, Sig=214,4 Ref=off 150010001.6561.6901.7331.7911.8511.8961.9512.13850000.5 DAD1 C, Sig=254,4 Ref=off mAU10001..66753411.7311.8511.89750000.51 MSD1 TIC, MS File ES-API, Pos, Scan, Frag: 702000001500001000005000000.51 Ion 1, MSD1 1,Target Mass 0 +H Positive, EIC=0.7:1.7 0.050-0.05-0.10.5 Integration Results for DAD1 B, Sig=214,4 Ref=off11.522.5min1.521.511.52.2852.047mAU22.0472.5min2.1362.25322.0712.5min2.5min RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------| 1.66 0.02 3.33 3.08 0.04 ND 1.69 0.02 3.97 3.72 0.05 ND 1.73 0.02 1.26 1.36 0.02 ND 1.79 0.02 9.34 8.00 0.11 ND 1.85 0.02 6.49 5.17 0.08 ND 1.90 0.02 6.03 5.63 0.07 ND 1.95 0.01 0.54 1.33 0.01 141 2.05 0.06 8113.68 2105.64 99.12 582 2.14 0.04 35.10 15.90 0.43 582 2.28 0.03 5.71 3.21 0.07 ND Integration Results for DAD1 C, Sig=254,4 Ref=off RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------| 1.65 0.02 0.72 0.59 0.01 ND 1.67 0.02 1.25 0.24 0.02 ND 1.73 0.02 1.55 1.20 0.03 ND 1.85 0.02 3.87 3.06 0.07 NDLCMS-02 7/17/2017 12:41:34 ZLJ_587Page 1 of 3

MS Report from Instrument: LCMS-02 1.90 0.02 3.73 3.56 0.07 ND 2.05 0.06 5555.07 1530.62 99.35 582 2.14 0.04 22.34 10.20 0.40 582 2.25 0.03 3.14 0.00 0.06 ND Integration Results for MSD1 TIC, MS File RetTim Width Area Height Area% MS(+)|-------|--------|--------------|--------------|--------|------| 2.07 0.09 1228886.63 227839.08 100.00 582LCMS-02 7/17/2017 12:41:34 ZLJ_587Page 2 of 3

MS Report from Instrument: LCMS-02Ret. Time: 2.07 <<<< POSITIVE SPECTRA >>>> ES-API Positive60000500004000030000 407.220000100000200300400500600700800m/z 583.2 584.3 582.3LCMS-02 7/17/2017 12:41:34 ZLJ_587Page 3 of 3