专利名称：MULTI-PARTICULATE FORM OF
MEDICAMENT, COMPRISING AT LEAST TWODIFFERENTLY COATED FORMS OF PELLET
发明人：BECKERT, THOMAS,PETEREIT, HANS-ULRICH,DRESSMAN, JENNIFER,RUDOLPH,MARKUS
申请号：EP01933676.7申请日：20010309公开号：EP1248599B1公开日：20071205
摘要：The invention relates to a multi-particulate form of medicament, suitable forthe uniform release of a pharmaceutical agent in the upper intestine and the lowerintestine, containing at least two forms of pellets, A and B, the core of which contains apharmaceutical agent and with different polymer coatings which permit the release ofthe agent at different pH values. Said forms are characterised in that pellet form A isprovided with an inner polymer coating, permitting a sustained release of agent and anexternal coating, resistant to gastric juice, which rapidly dissolves at a pH above 5.5. Pelletform B is provided with a polymer coating, which releases less than 20 % of the agent atpH 6.8 in 6 hours according to the USP release test and at pH 7.2 releases more than 50% in 6 hours. The invention further relates to a method for production of the multi-particulate form of medicament and the use of pellet forms A and B for the productionof the form of medicament.
申请人：EVONIK ROEHM GMBH,EVONIK ROEHM GMBH,EVONIK ROEHM GMBH
地址：DE
国籍：DE
代理机构：Gottschalk, Michael
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