Cilnidipine_132203-70-4_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Cilnidipine132203-70-4HY-17404492.52C27H28N2O7>98%Solubility:DMSO > 20 mg/mL Ethanol > 10mg/mLMechanisms: Pathways:Membrane Transporter/Ion Channel; Target:Calcium Channel gyBiological Activity:Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive,sympatholytic and neuroprotective activity. IC50 value: Target: calcium channel Cilnidipine has displayed renal and vascular protective effects and improved baroreflex sensitivity inpatients with hypertension. It has also demonstrated neuroprotective effects in a rat focal brainischemia model by removing free radicals and activating the phosphatidylinositol 3-kinase pathway.References:[1]. Masuda T, Ogura MN, Moriya T, et al. Beneficial effects of L- and N-type calcium channelblocker on glucose and lipid metabolism and renal function in patients with hypertension and type IIdiabetes mellitus. Cardiovasc Ther. 2011 Feb;29(1):46-53. doi: 10.1111/j.1755-5922.2009.00126.x. [][2]. Morimoto S, Yano Y, Maki K, Iwasaka T. Renal and vascular protective effects of cilnidipine inpppatients with essential hypertension. J Hypertens. 2007 Oct;25(10):2178-83. [3]. Takahara A, Konda T, Enomoto A, Kondo N. Neuroprotective effects of a dual L/N-type Ca(2+)channel blocker cilnidipine in the rat focal brain ischemia model. Biol Pharm Bull. 2004Sep;27(9):1388-91. [4]. Murai Y, Uneyama H, Ishibashi H et al. Preferential inhibition of L- and N-type calcium channelsin the rat hippocampal neurons by cilnidipine. Brain Res. 2000 Jan 31;854(1-2):6-10. ...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr