BIOLOGICALLY ACTIVE PEPTIDES

专利名称：BIOLOGICALLY ACTIVE PEPTIDES发明人：ROBERTO DE CASTIGLIONE,LUIGIA

GOZZINI,PIER CARLO

MONTECUCCHI,GIUSEPPE PERSEO

申请号：AU2104183申请日：19831107公开号：AU2104183A公开日：19840517

摘要：A peptide of formula (I): X-A-B-C-Trp-D-Y wherein X represents hydrogen, or aterminal nitrogn protecting group selecting from the group consisting of the acyl,aromatic oxycarbonyl, alkyl, aralkyl and aliphatic oxycarbonyl; A represent a valence bondor a L- alpha -amino acid residue; B represent a L- alpha -imino acid residue or a L- alpha -amino acid; C represent a L- alpha -imino acid residue or a neutral L- alpha -amino acidresidue; D represents a valence bond or a L- alpha -amino acid residue; and Y representshydroxy, an amino group or a group of the formula OR, NHR, NR2 or NH-NH-R', whereinR represents a straight chain, branched chain or cyclic (including fused or bridged ring)alkyl group having up to 11 carbon atoms, optionally being substituted; a phenyl groupor an aralkyl group having from 7 to 9 carbon atoms; and R' represents hydrogen, any ofthe groups which R may represent; a straight chain, branched chain or cyclic aliphatic acylgroup having from 1 to 11 carbon atoms, optionally substituted by hydroxy, an aminogroup or a halogen atom; an aromatic acyl group, optionally substituted by hydroxy,amino, or a halogen atom; a straight chain, branched chain or cyclic aliphatic oxycarbonylgroup having from 3 to 11 carbon atoms, or an aromatic oxycarbonyl group.

申请人：FARMITALIA CARLO ERBA S.P.A.

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