专利名称：Process for making 5-lipoxygenase inhibitors
having varied heterocyclic ring systems
发明人：Norris, Timothy, Pfizer Inc.,Lambert, John
Francis, Pfizer Inc.,Hnatow, Megan Elizabeth
申请号：EP00307014.1申请日：20000816公开号：EP1081143A1公开日：20010307
摘要：A novel process intermediate, tetrahydro-4-[3-(4-fluorophenyl)thio]phenyl-2H-pyran-4-carboxamide, of the formula: is described, as well as its use in a process ofpreparing 5-lipoxygenase inhibitors of the formula: which comprises establishing areaction mixture consisting of: - and - an electron deficient monocyclic or benzo-fusedbicyclic N-heterocycle containing two nitrogen atoms of the formula: in an aproticsolvent; in the presence of a carbonate of the formula: (M)-CO, where M is an alkali metal,Group 1/Ia element, selected from the group consisting of lithium, Li; sodium,Na;potassium, K; rubidium, Rb; and cesium, Cs; followed by heating of said reaction mixtureunder a nitrogen atmosphere; whereby there is produced the desired compound of theabove-recited formula.
申请人：Pfizer Products Inc.
地址：Eastern Point Road Groton, Connecticut 06340 US
国籍：US
代理机构：Wood, David John
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