专利名称：USE OF CDK9 AND BRD4 INHIBITORS TO
INHIBIT INFLAMMATION
发明人：HAUDENSCHILD, Dominik,YIK, Jasper申请号：EP15850918.2申请日：20151013公开号：EP3206749A4公开日：20180620
摘要：Provided are methods for the combined use of cyclin-dependent kinase 9(CDK9) inhibitors and bromodomain containing 4 (BRD4) inhibitors to reduce, inhibitand/or prevent cartilage degradation and systemic traumatic inflammation. A
combination of CDK9 inhibitors and BRD4 inhibitors can be used to reduce, inhibit and/orprevent cartilage degradation and loss of cartilage viability during allograft storage. Acombination of CDK9 inhibitors and BRD4 inhibitors can be used as a post-injuryintervention treatment to reduce, inhibit and/or prevent the acute cellular responsesthat lead to future cartilage degradation and osteoarthritis.
申请人：The Regents of the University of California
地址：1111 Franklin Street, 12th Floor Oakland, CA 94607-5200 US
国籍：US
代理机构：Patent Boutique LLP
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