BIGUANIDE DERIVATIVE, A PREPARATION METHOD THEREOF

专利名称：BIGUANIDE DERIVATIVE, A PREPARATION

METHOD THEREOF AND A

PHARMACEUTICAL COMPOSITIONCONTAINING THE BIGUANIDE DERIVATIVEAS AN ACTIVE INGREDIENT

发明人：KIM, SUNG WUK,JUN, SUNG SOO,MIN,

CHANG HEE,KIM, YOUNG WOONG,KANG,MIN SEOK,OH, BYUNG KYU,PARK, SEHWAN,KIM, YONG EUN,KIM, DUCK,LEE, JISUN,OH, JU HOON

申请号：EP11731936申请日：20110106公开号：EP2522653A4公开日：20130612

摘要：A biguanide derivative compound with N4-N5 substitution, which is representedby Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing thesame, and a pharmaceutical composition containing the same as an active ingredient areprovided. The biguanide derivative may exhibit excellent effect on activation of AMPK andinhibition of cancer cell proliferation in a low dose, compared with conventional drugs,and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia,hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycysticovarian syndrome, metabolic syndrome, cancer, etc.

申请人：HANALL BIOPHARMA CO., LTD.

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