Intrapulmonary delivery of aerosolized formulation

专利名称：Intrapulmonary delivery of aerosolized

formulations

发明人：Lester John Lloyd,Peter M. Lloyd,Reid M.

Rubsamen

申请号：US08/065660申请日：19930521公开号：US05709202A公开日：19980120

摘要：Liquid, flowable formulations including aqueous formulations of a

pharmaceutically active drug are packaged in individual dosage unit containers whichcontainers are interconnected to form a cellular array designed to be integrated into adispensing device capable of individually opening dosage unit containers and aerosolizingthe contents through a nozzle for delivery to a patient. The cellular array is comprised ofa plurality of containers with each container having an opening(s) thereon from which adrug-containing formulation may be aerosolized. The dispensing device is a hand-held,self-contained, portable device comprised of a means for removing covers from thecontainers and automatically dispensing the formulation from individual containers,preferably in response to a signal obtained as a result of measuring the inspiratory flowof a patient. The cellular array is loaded into the dispensing device to form a systemwhich can be used in a method of delivering drugs to a patient via the intrapulmonaryroute. In a preferred embodiment each container includes an opening covered by amembrane having a plurality of pores therein wherein the pores have a diameter of about0.5 microns to 50 microns and the dispensing device includes a vibrating device which

creates a vibration frequency such that formulation forced through the pores isaerosolized to particles having a diameter of about 1 micron to 100 microns.

申请人：ARADIGM CORPORATION

代理人：KarlBozicevic & Reed LLP Bozicevic

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