专利名称：IMPROVEMENTS IN ANTISENSE OLIGOMERS,
DELIVERY OF ANTISENSE OLIGOMERS, ANDIDENTIFICATION OF ANTISENSE OLIGOMERTARGETS
发明人：WOOLF, Tod, M.,BECK, Terry, B.申请号：EP00950992.8申请日：20000803公开号：EP1206532A2公开日：20020522
摘要：Antisense oligomers which possess improved properties over those taught inthe prior art are disclosed. Preferably, oligomers for delivery to a cell comprising at leastone nucleomonomer having a silicon-based 2'OH protecting group, e.g., a tertbutyldimethyl-silyl group. Oligomers of between about 7 and about 12 nucleomonomers inlength which are complementary to a site on an RNA target molecule selected from thegroup consisting of: the extreme 5' terminus of the RNA molecule, a 5' splice junction ofthe RNA molecule, and a 3' splice junction of the RNA molecule are provided. Oligomerscomprising a neutral backbone which have been modified to comprise at least onecharged group are also disclosed. In addition, methods of identifying an oligomercomplementary to a cellular gene involved in a physiological process are provided.
申请人：Sequitur, Inc.,Trilink Biotechnologies, Inc.
地址：14 Tech Circle Natick, MA 01760 US,Suite 101,6310 Nancy Ridge Drive San Diego,CA 92122 US
国籍：US,US
代理机构：Lock, Graham James
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