METHOD AND COMPOSITION OF AN ORAL PREPARATION OF I

专利名称：METHOD AND COMPOSITION OF AN ORAL

PREPARATION OF ITRACONAZOLE

发明人：JUNG, Jae, Young,Choongwae Research

Laboratory,KIM, Kye, Hyun,ChoongwaeResearch Laboratory,LEE, Sang,Heon,Choongwae Research

Laboratory,HONG, Ji, Woong,ChoongwaeResearch Laboratory,PARK, Jong,

Woo,Choongwae Research Laboratory,LEE,Kyu, Hyun,Choongwae Research Laboratory

申请号：EP98959284.5申请日：19981217公开号：EP1039909A1公开日：20001004

摘要： Oral preparation of itraconazole improved bioavailability, which is obtainable bythe following steps: i) dissolving 1 weight part of itraconazole and 0, 5-5, 0 parts byweight of inert hydrophilic polymer subordinate to pH which is at least one polymerselected from the group consisting of diethylamino acetate polyvinyl acetal and amethacrylate copolymer of amino-alkyl, with at least one solvent selected from thegroup consisting of methylene chloride, chloroform, ethanol and methanol, ii) subjectingthe resulting solution obtained after the dissolution to a dispersing process and spraydrying to prepare a solid solution, and iii) providing said prepared solid solution for themanufacture of the oral preparation.

申请人：Choongwae Pharma Corporation

地址：698, Shindaebang-dong,Dongjak-ku Seoul 156-757 KR

国籍：KR

代理机构：Fleck, Hermann-Josef, Dr.-Ing.

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